John A. Thomas

Despite being regarded as the most common toxicological target in the endocrine system, the adrenal gland has often been neglected in regulatory testing. Adrenal Toxicology addresses the increased interest in adrenocortical toxicology and the need for a resource that makes techniques available to examine adrenal endocrine disruption.

Examining current techniques and the latest advancements, Adrenal Toxicology reviews the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. This text provides information on the range of drugs and chemicals that affect adrenocortical function and suggests standardized approaches for in vivo and in vitro assessment. This volume also presents recent developments in the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Focused extensively on the toxic effect of chemicals on the cardiovascular system, Cardiovascular Toxicology, Fourth Edition is comprised of several key sections beyond cardio and vascular toxicity, such as principles of myocardial cell injury and key methods of assessing cardiovascular function.

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs.

The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed.

This third edition of Immunotoxicology and Immunopharmacology provides the latest methodologies for estimating human health risk from exposure to drugs and chemical agents. This edition includes new sections on immunopharmacology and immunotoxicology of therapeutics, developmental immunotoxicology, and neuroimmunology. With a greater focus on mechanisms and risk assessment, it features a broader scope with increased information on autoimmunity, hypersensitivity responses, inflammation, and wildlife species. Written by internationally recognized immunotoxicologists and immunopharmacologists, this text identifies how exposure to chemicals and drugs can alter normal functioning.

This book replaces Intestinal Toxicology, one of the original books in the Target Organ series. It provides a complete, multidimensional overview of the entire gastrointestinal system involved in the toxicity of exogenous agents. The book describes normal structures and functions, regulatory mechanisms of control, and the role of absorption and metabolism in the systemic toxicity of toxic agents. It includes detailed treatment of the mechanisms of action of substances on the GI tract and how such effects can adversely affect the functioning of other systems in the body. The book also covers pharmacology, and histopathology, as well as complications and susceptibilities arising from specific disease states.

Intended as an extension, rather than a revision, of the previous editions, Toxicology of the Lung, Fourth Edition provides the most up-to-date treatment of inhalation toxicology that treats the subject from a target organ perspective. Seventeen of the eighteen chapters are contributed by entirely new authors, leading international authorities in their respective specialties. As with the previous editions, this book presents the latest advances in the understanding of how the lung responds to airborne contaminants. It discusses the assessment of nanomaterials, pulmonary administration of new therapeutics, health effects of inhaled particulate matter from diesel exhaust, and respiratory genomics.

A benchmark volume, Toxicology of the Pancreas pulls together information in this neglected area of toxicological research and highlights fundamental research performed in the last ten years. Leaders in the field discuss important structures, the detoxification and toxification process at the cellular and sub-cellular level, the distribution of phase 1 and phase 2 drug-metabolizing enzymes and their role in pancreatic disease, and the role of diet and toxicants on pancreatic disease. Illustrated with histological, electron microscopical, and immunohistochemical formats, this book provides a comprehensive and novel presentation of biological and toxicological data

Toxicology of the Thyroid is the first and only comprehensive reference on the impact of environmental chemicals on the thyroid gland, thyroid homeostasis, and secondary adverse outcomes. This book includes a background of basic biology with coverage of the anatomy and physiology of the thyroid. It describes thyroid hormones and homeostasis in both adult and developing thyroids and includes testing protocols for environmental and other agents of toxicity. Looking toward scientific research needs, this text also provides an understanding of how data can be used in risk assessment. This is an ideal reference for toxicologists interested in endocrine, reproductive, and developmental toxicology.