Category - "Pharmaceutical Science"

Covering regulatory requirements stipulated by the FDA, this book delineates the organization, planning, verification, and documentation activities and procedural controls required for compliance.

Exploring the growth in knowledge of particle properties and the variety of technological advances in particle manufacture, this book helps readers understand particulate science and its use in the industry. The authors cover particulate material, its form and production, sampling from bodies of powder, particle size descriptors and statistics, behavior of particles, instrumental analysis, particle size measurement and synergy of adopted techniques, physical behavior of a powder, and in vitro and in vivo performance criteria. They draw the components of particulate science into a single concise description of their integration in the context of product development.

This practical, user-friendly, and informative text surveys basic principles of toxicology. It is an invaluable guide to evaluating toxicity and related data, approaching toxicity testing and interpretation, and understanding the concepts of hazard prediction and risk assessment and management.

Taking a unique industrial perspective that reinforces theory and develops valuable analytical and interpretation skills, this book examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. Professionals with extensive experience in drug discovery and development, as well as specialized knowledge of the individual topics, contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics, and drug-drug interactions.

This classic handbook provides twenty-one SOPs ready for immediate use or for adaptation to readers' requirements, allowing them to benchmark their existing SOPs against an internationally accepted set of SOPs. It contains SOPs applicable to the four major entities in the clinical development process: the sponsor, the clinical monitor, the investigator, and the Institutional Review board. The language ranges from the specific to the very general, depending on the activity described and the number and breadth of the existing regulations governing it. The handbook supplies readers with a blueprins for setting up the procedural guidelines their companies need.

Few scientists have access to the multidisciplinary experience needed for successful assay development and high-throughput screening (HTS) in drug discovery. Designed to give researchers a boost, this text integrates the experience of diverse experts who offer fundamental practical guidance across numerous situations. It introduces emerging technology that allows scientists to identify and capture relevant information. It instructs in how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. It also identifies critical targets of relevance in drug discovery and treats each individually in terms of the parameters needed for successful assay development.

Examining how to maintain assured quality in clinical trial research, A Practical Guide to Quality Management in Clinical Trial Research provides solid foundations, tips, and techniques for establishing a quality system that will comply with the relevant regulations. This book offers useful information for various standards including Good Laboratory Practice, Good Clinical Practice, and Good Manufacturing Practice. It gives detailed explanations of how to prepare, update, and maintain Standard Operating Procedures and also includes advice on training and development of personnel. This text is ideal for clinical trial monitors and quality assurance personnel in the pharmaceutical industry.

Focusing on the three most critical components that successfully bring an API to market-process development, manufacturing, and governmental regulation and approval-this reference serves as a step-by-step guide to the planning and clear understanding of the bulk manufacturing of APIs. It offers current and timely discussions of the process development cycle, design engineering, the approval process, quality control and assurance, and validation, as well as plant manufacturing activities including materials management, maintenance, and safety. Filling a gap in the literature, this guide covers all the essential information required to effectively plan and execute manufacturing APIs.

Reflecting rapid innovations in the field, Acute Coronary Syndromes, Second Edition uncovers the structural, physiological, and functional foundations of acute coronary syndromes-including the latest advances in the causes of inflammation and embolization, therapeutics, intravenous and oral antiplatelet agents, and anticoagulants.

Presents original theories in the cost-effectiveness of diagnostic therapies of acute coronary syndromes!

Providing seven new chapters demonstrating the most up-to-date information on invasive and conservative management strategies, aspirin resistance, and public health implications, Acute Coronary Syndromes, Second Edition

illustrates current approaches to bedside platelet function testing

considers novel ideas in combined fibrin and platelet-lysis for myocardial infarction

describes recent treatments with tirofiban, eptifibatide, clopidogrel, and low-molecular- weight heparins

and more!
Written by over 40 international experts in the field, Acute Coronary Syndromes, Second Edition is a monumental reference for cardiologists; internists; epidemiologists; molecular and cell biologists; pharmacologists; emergency room personnel; and graduate and medical school students in these disciplines.