A Guide to Practical Toxicology

This practical, user-friendly, and informative text surveys basic principles of toxicology. It is an invaluable guide to evaluating toxicity and related data, approaching toxicity testing and interpretation, and understanding the concepts of hazard prediction and risk assessment and management.

A Guide to Practical Toxicology:

• examines how to evaluate various groups of chemicals—pharmaceuticals, cosmetics, and agrochemicals


• provides insights on toxicity determination, normality and naturality, prediction, and regulation

Two all-new chapters cover:

• safety pharmacology


• evaluation of different chemical classes

Introduction to toxicology: the necessity of measurement. Normality: definition and maintenance. Determination of toxicity: basic principles. Determination of toxicity in vitro. Safety Pharmacology. Determination: general and reproductive toxicology. Determination: genotoxicity and carcinogenicity. Determination: irritation and sensitization. Determination: environmental toxicology and epidemiology. Interpretation. Prediction of hazard. Background to risk due to toxicity. Risk assessment in practice and setting exposure limits. Risk assessment and management in the workplace. Risk assessment: carcinogenicity; the environment; evolution and overview of risk assessment. Evaluation of specific groups of chemicals. The future of toxicity testing.