Apoptosis, Cell Signaling, and Human Diseases
Molecular Mechanisms, Volume 2

Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer. These comprehensive volumes integrate the most innovative and current findings. The contributors are at the forefront of scientific discovery.

Section I. Kinases and Phosphatases



Significance of Protein Kinase A in Cancer

Maria V. Nesterova and Y. S. Cho-Chung



Protein Kinase C and Cancer

Mary E. Reyland



The Role of PI3K-Akt Signal Transduction in Virus Infection

Samantha Cooray



Cyclin-Dependent Kinase 5: A Target for Neuroprotection?

Frank Gillardon



Critical Roles of the Raf/MEK/ERK Pathway in Apoptosis and Drug Resistance

James A. McCubrey, Fred E. Bertrand, Linda S. Steelman, Fumin Chang, David M. Terrian, and Richard A. Franklin



MAP Kinases Signaling in Human Diseases

Philippe Roux and J.Blenis



Serine/Threonine Protein Phosphates in Apoptosis

Gro Gausdal, Camilla Krakstad, Lars Herfindal, and Stein Ove Doskeland



Urokinase/Urokinase Receptor-Mediated Signaling in Cancer

Sreerama Shetty, and Steven Idell



Section II. Molecular Basis of Cell Death



Signaling Pathways That Protect the Heart Against Apoptosis Induced by Ischemia and Reperfusion

Zheqing Cai and Gregg L. Semenza



Cyclooxygenase-2 Gene Expression: Transcriptional and Posttranscriptional Controls in Intestinal Tumorigenesis

Shrikant Anant and Sripathi M. Sureban



Death Receptors: Mechanisms, Biology and Therapeutic Potential

Sharmila Shankar and Rakesh Srivastava



DNA Damage-Dependent Apoptosis

Tomasz Skorski



The Role of Proteasome in Apoptosis

Peter Low



Apoptosis Induction in T Lymphocytes by HIV

Maria Saveria Gilardini Montani



Inhibitors of Apoptosis Proteins and Caspases

Jai Yu, John Silke and Paul G. Ekert



Intracellular Pathways Involved in DNA-Damage and Repair to Neuronal Apoptosis

Maurizio Memo



The Biology of Caspases

Tasman James Daish and Sharad Kumar